Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene. Research output: Contribution to journal › Journal article › Research › peer-review

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osti.gov journal article: prolonged action of succinylcholine at the height of acute radiation sickness.

8 Jul 2019 A guide to diagnosis and management for prolonged paralysis after administration of suxamethonium. 13 May 2017 Acetylcholine and succinylcholine. Mechanism of Succinylcholine ○ Roles of Succinylcholine on muscles ○ Location and effects of Acetylcholine and Succinylcholine; 3. Malignant hyperthermia ○ Prolonged paralysis. 12 May 2013 She failed to recover from the effects of scoline given during surgery. respiratory paralysis unexpectedly persists for a prolonged period of  23 Jun 2017 metabolized by cholinesterase, anticholinesterase drugs may prolong rather than shorten paralysis. Succinylcholine has no direct effect on the  anticholinesterase drugs may prolong rather than shorten paralysis.

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Mutations in the butyrylcholinesterase enzyme (BChE) can result in prolonged duration of action of the neuromuscular blocking agents, succinylcholine and  Various physiologic states can alter the expected effects of succinylcholine; of prolonged neuromuscular block after administration of succinylcholine in such  29 Sep 2020 Rocuronium duration of action was prolonged in patients with renal disease [14]. Conclusions. The necessity of succinylcholine has come into  A prolonged effect is common in: ileus, heart failure, malignancy, especially bronchus-CA, potassium release by succinylcholine occurs in these patients is not  It was learned that the patient was administered succinylcholine during both of Deficiency of this enzyme from any cause can lead to prolonged apnea and in the activity of pseudocholinesterase enzyme and a decline in the block eff Patients who receive neuromuscular blocking agents for a prolonged period may Various physiologic states can alter the expected effects of succinylcholine;  Patients who have been immobilised for prolonged periods of time may be at Suxamethonium has no direct effect on the myocardium, but by stimulation of both succinylcholine (which possesses clinically insignificant depolarising mu 22 Nov 2020 Note: the depolarizing neuromuscular blocker suxamethonium will have a prolonged effect (up to 12 h) due to acetylcholinesterase inhibition. 3 Mar 2021 Succinylcholine.

/06/potassium-phosphate-and-succinylcholine-by-advanced-pharma​-recall Pain-relieving success as well as side-effects were intentional beyond a unit of although these symptoms disappeared together with persistent body process.

Numerous reviews have concluded that succinylcholine provides better intubating conditions than rocuronium, but other observational studies have reported that when rocuronium is used at a dose higher than 1 mg/kg, intubation is as successful as with succinylcholine. 11-13 Consequently, surveys have reported a marked increase in rocuronium use in emergency settings.

Impact of the COVID-19 pandemic on long-term care facilities. streptokinase 0 d00375 streptozocin 0 d00376 succinylcholine 0 d00377 sucralfate 0 d00378 

Mechanism of Succinylcholine ○ Roles of Succinylcholine on muscles ○ Location and effects of Acetylcholine and Succinylcholine; 3. Malignant hyperthermia ○ Prolonged paralysis.

INTRODUCTION: Mutations in the butyrylcholinesterase enzyme (BChE) can result in prolonged duration of action of the neuromuscular blocking agents, succinylcholine and mivacurium, as BChE hydrolyses these drugs. Hereditary low BChE activity can cause extensively prolonged apnoea during general anaesthesia when these drugs are used. for prolonged duration of succinylcholine when it is used to treat post-extubation laryngospasm, particularly when it is administered at more than 50% recovery of non-depolarizing block. Similarly, the dose (not just the timing) of succinylcholine may impact its effects on recovery from a non-depolarizing block: a small dose of succinylcholine Prolonged effect of succinylcholine after neostigmine and pyridostigmine administration in patients with renal failure.
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Prolonged effect of succinylcholine

Conclusions.

There is one case report [3] published where a dose of neostigmine 2 hours prior to a dose of succinylcholine resulted in prolonged neuromuscular blockade. The two most serious side effects associated with succinylcholine are malignant hyperthermia and hyperkalemia.
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Muscle relaxant doses should be reduced by 25-50%. Fasciculations will likely be absent with succinylcholine administration. Magnesium has cardiovascular effects ranging from hypotension and bradycardia to complete heart block/cardiac arrest. A prolonged PR interval and widened QRS may be seen on EKG.

3 Mar 2021 Succinylcholine. , the only receptors and causes a prolonged Based on the duration of action, NMJ-blocking drugs are useful adjuncts to. 11 Mar 2013 agent poisoning, would rapidly reverse the effects of succinylcholine. concerns of apnea, prolonged hypoxia and cardiovascular collapse.


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2015-02-13 · Succinylcholine apnea. Clinical interest in BChE abnormalities and pharmacology stemmed from observations that certain patients given succinylcholine develop prolonged apnea. The enzyme present in the plasma of affected individuals differs from normal BChE. Mutations of the gene coding for BChE give rise to a variety of biochemical phenotypes.

Use of neuromuscular monitoring to detect prolonged effect of succinylcholine or mivacurium: three case reports Publikation : Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review Muscle relaxant doses should be reduced by 25-50%. Fasciculations will likely be absent with succinylcholine administration. Magnesium has cardiovascular effects ranging from hypotension and bradycardia to complete heart block/cardiac arrest. A prolonged PR interval and widened QRS may be seen on EKG. Wichmann, Sine, et al.